Alpha-lipoic acid: Alpha-lipoic acid is a strong antioxidant that can renew other antioxidants in the body and chelate metals from the body. Selenium: Selenium may help remove mercury from the body.
Alpha-lipoic (ALA) and dihydrolipoic acid (DHLA) are useful detoxifying drug metabolites. As cofactors, ALA and DHLA have a central function in the mitochondrial energy metabolism. ALA and DHLA can increase the excretion of methylmercury from cells.
Alpha-lipoic acid, a sulphur-containing fatty acid, also known as thioctic acid, occurs as a coenzyme and component of the pyruvate dehydrogenase complex in the mitochondria of almost all living things with a cell nucleus. As a natural substance, it is considered a safe, well tolerated chelating agent.
These results were consistent with the in vitro results, showing that ALA results in a significant reduction of iron storage in the liver and intestine and in the expression of FPN1.
While ALA is often touted as primarily a powerful antioxidant, ALA seems to have potentially beneficial effects on fat loss as well as prevention of further fat gain. Multiple studies have shown that ALA stimulates the activation of an enzyme called 5'-adenosine monophosphate kinase (AMPK) in muscle and fat tissue.
► ALA is a powerful antioxidant effects on fatty liver. ► ALA prevents degenerations and induces liver regeneration. ► ALA induces liver regeneration by inhibiting apoptosis. ► ALA may be cause transformation of HSCs into hepatocyte.
Effect of Lipoic Acid in Atherosclerosis. Many studies have confirmed that LA can improve vascular function and decrease the atherosclerotic plaque burden [84, 85].
Furthermore, a recently published study demonstrated that the oral combination of alpha-lipoic acid (800 mg), folic acid (400 mg), apple SelectSIEVE® (300 mg), and myo-inositol (2000 mg), administered twice daily for three months, significantly enhanced testosterone production in men with subclinical hypogonadism [55].
α-Lipoic acid protects kidney from oxidative stress and mitochondrial dysfunction associated to inflammatory conditions.
Side effects are generally rare and may include insomnia, fatigue, diarrhea, and skin rash. Alpha-lipoic acid can lower blood sugar levels, so people with diabetes or low blood sugar should take alpha-lipoic acid only under the supervision of their health care provider.
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