Spironolactone is a diuretic that treats high blood pressure and heart failure. It can also reduce swelling related to heart, kidney or liver disease. It helps your kidneys remove more fluid and salt from your blood through your pee without losing too much potassium. The brand name for this medication is Aldactone®.
Aldactone is a brand-name oral tablet that's prescribed for heart failure, high blood pressure, and other conditions. Aldactone contains the active drug spironolactone. It's a type of drug called a potassium-sparing diuretic.
In low doses (median 25 mg daily), it has been shown to substantially lower BP in several uncontrolled trials in resistant arterial hypertension, leading to a significant reduction of systolic blood pressure (SBP) between 14 and 36 mm Hg and diastolic between 7 and 12.5 mm Hg.
Spironolactone is used in combination with other medicines to treat high blood pressure (hypertension) and heart failure. Lowering blood pressure can reduce the risk of strokes and heart attacks. Spironolactone is also used to lessen the need for hospitalization for heart failure.
When will I feel better? For oedema, spironolactone usually starts working after 2 or 3 days, but it can sometimes take longer. For high blood pressure (hypertension), it can take up to 2 weeks for spironolactone to work.
ALDACTONE can cause hyperkalemia. This risk is increased by impaired renal function or concomitant potassium supplementation, potassium-containing salt substitutes or drugs that increase potassium, such as angiotensin converting enzyme inhibitors and angiotensin receptor blockers [see DRUG INTERACTIONS].
Amlodipine has an average rating of 4.3 out of 10 from a total of 828 ratings on Drugs.com. 28% of reviewers reported a positive effect, while 54% reported a negative effect. Spironolactone has an average rating of 6.9 out of 10 from a total of 699 ratings on Drugs.com.
The usual dose for adults is: heart failure – 25mg once a day as a starting dose. Depending on how well it works for you, the dose can be from 25mg every other day to 50mg once a day. build-up of fluid caused by liver disease (ascites) – between 100mg and 400mg a day.
Aldosterone excess is common in patients with resistant hypertension, and addition of spironolactone or amiloride to the standard 3-drug antihypertensive regimen is effective at getting the blood pressure to goal in most of these patients.
Aldactone 50 Tablet is a medicine known as a diuretic (water pill). It is mainly used in the treatment of heart failure and high blood pressure. It reduces the swelling (edema) caused by some other conditions. This medicine is also used to treat low potassium levels in the body (hypokalemia).
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