Because amitriptyline can make you drowsy, you should not cycle, drive or use machinery for the first few days of taking it, until you know how it affects you. It may also be best to try it out when you don't have to get up for work the next day. In rare cases, people can have serious side effects to amitriptyline.
Side effects such as a dry mouth and constipation are common. They're usually mild and go away after a couple of weeks. It's best to take amitriptyline in the evening or before you go to bed. This is because it can make you feel sleepy.
It can cause daytime sleepiness and grogginess, which can interfere with daily life. It can reduce the overall quality of sleep in those who take it. It does not treat the root cause of the problem and so is not a good long-term treatment for insomnia.
Amitriptyline, doxepin, imipramine and trimipramine are more likely to make you sleepy than other tricyclic antidepressants are. Taking these medicines at bedtime may help. Amitriptyline, clomipramine, doxepin, imipramine and trimipramine are more likely to cause weight gain than other tricyclic antidepressants are.
Amitriptyline is usually taken once a day. It can make you feel sleepy so it is best to take it in the evening or 1 to 2 hours before going to bed.
Chronic treatment with amitriptyline desensitizes presynaptic autoreceptors and heteroreceptors, producing long-lasting changes in monoaminergic neurotransmission. [7] Amitryptiline is more sedating and has increased anticholinergic properties than other TCAs.
Patients considered to be much or very much improved on the CGI were 41% in the adinazolam group, 64% in the amitriptyline group, and 20% in the diazepam group, indicating significant superiority of amitriptyline as com- pared to diazepam (p = 0.006).
The side effects, toxicity, and lethality in overdose, the risk of switch to manic state in predisposed individuals and the invention of selective serotonin reuptake inhibitors (SSRIs), another class of antidepressants with a better safety profile, made amitriptyline a less preferable medication [2].
Amitriptyline (maximum of 150 mg/day), nortriptyline (maximum of 50 mg/day), and imipramine (maximum of 80 mg/day) were given for an average of 6 months of treatment. There was a mean weight increase of 1.3-2.9 lbs/month, which led to an average total weight gain of 3–16 lbs, depending on drug, dose and duration.
It has a sedative effect and may make you drowsy, so you should take it an hour or two before bed, but no later than 8pm.
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